Počet záznamů: 1

Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic

  1. 1.
    0356231 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Rössner ml., Pavel - Tabashidze, Nana - Dostál, Miroslav - Nováková, Zuzana - Chvátalová, Irena - Špátová, Milada - Šrám, Radim
    Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic.
    Environmental Health Perspectives. Roč. 119, č. 2 (2011), s. 265-271 ISSN 0091-6765
    Grant CEP: GA MŽP(CZ) SP/1B3/50/07
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: air pollution * biomarkers * genetic polymorphisms
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 7.036, rok: 2011

    We investigated associations between the levels of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes and pregnancy outcomes (intrauterine growth restriction, IUGR, low birth weight, LBW). Multivariate-adjusted logistic regression revealed that above-median 8-oxodG levels are the only factor significantly associated with the risk of IUGR (OR; 95% CI: 1.56; 1.07-2.37; p=0.022). Above-median levels of 8-oxodG were associated with an increased risk of LBW (OR; 95% CI: 1.88; 1.15- 3.06; p=0.011). Other variables associated with LBW included the newborn’s gender and gestational age, maternal smoking and haplotypes in the promoter region of the gene encoding mannose-binding lectin 2.
    Trvalý link: http://hdl.handle.net/11104/0194808