Počet záznamů: 1

Systematically fragmented genes in a multipartite mitochondrial genome

  1. 1.
    0356039 - UMG-J 2013 RIV GB eng J - Článek v odborném periodiku
    Vlček, Čestmír - Marande, W. - Teijeiro, S. - Lukeš, Julius - Burger, G.
    Systematically fragmented genes in a multipartite mitochondrial genome.
    Nucleic Acids Research. Roč. 39, č. 3 (2011), s. 979-988 ISSN 0305-1048
    Grant CEP: GA MŠk(CZ) 1M0520; GA ČR(CZ) GA204/09/1667
    Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z60220518
    Klíčová slova: mtDNA genome * gene fragmentation * RNA editing
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 8.026, rok: 2011

    The most bizarre mitochondrial DNA (mtDNA) is that of the euglenozoan eukaryote Diplonema papillatum. The genome consists of numerous small circular chromosomes none of which appears to encode a complete gene. We examined how many genes are encoded by Diplonema mtDNA and whether all are fragmented and their transcripts trans-spliced. By employing most sensitive protein profile search algorithms and comparing genomic with cDNA sequence, we recognize a total of 11 typical mitochondrial genes. The 10 protein-coding genes are systematically chopped up into three to 12 modules of 60-350 bp length. The corresponding mRNAs are all trans-spliced. Our results open new intriguing questions about the biochemistry and evolution of mitochondrial trans-splicing in Diplonema.
    Trvalý link: http://hdl.handle.net/11104/0194664
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