Počet záznamů: 1

STIM1-Directed Reorganization of Microtubules in Activated Mast Cells

  1. 1.
    0355825 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Hájková, Zuzana - Bugajev, Viktor - Dráberová, Eduarda - Vinopal, Stanislav - Dráberová, Lubica - Janáček, Jiří - Dráber, Petr - Dráber, Pavel
    STIM1-Directed Reorganization of Microtubules in Activated Mast Cells.
    Journal of Immunology. Roč. 186, č. 2 (2011), s. 913-923 ISSN 0022-1767
    Grant CEP: GA ČR(CZ) GD204/09/H084; GA ČR GA204/09/1777; GA ČR GA301/09/1826; GA ČR GAP302/10/1759; GA MŠk LC545; GA MŠk(CZ) LC06063; GA AV ČR KAN200520701
    Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z50110509
    Klíčová slova: STIM1 * bonemarrow-derived mast cells * microtubules
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.788, rok: 2011

    This research article shows important role of STIM1 protein in activation of bone marrow-derived mast cells. During activation process, mast cells change intracellular level of calcium and present microtubule reorganization. The molecular mechanisms for control microtubule rearrangement during activation events are still unknown. Activation of mast cells results in generation of microtubule protrusions that are calcium dependent. Experiments with knockdown or reexpression of STIM1 protein, the key regulator of store-operated calcium entry, confirmed the important role of STIM1 in the formation of protrusions. This article propose that calcium plays an important role in the formation of microtubule protrusions in mast cells and that rearrangement of microtubules in activated mast cells depends on STIM1-induced calcium entry.
    Trvalý link: http://hdl.handle.net/11104/0194505
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