Počet záznamů: 1

Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation

  1. 1.
    0355817 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Philimonenko, Anatoly - Janáček, Jiří - Snyers, L. - Almeder, M. - Berger, W. - Schmidt, W. - Schofer, C. - Hozák, Pavel
    Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation.
    Journal of Structural Biology. Roč. 173, č. 2 (2011), s. 382-390 ISSN 1047-8477
    Grant CEP: GA MŠk LC545; GA MŠk(CZ) LC06063; GA MŠk 2B06063
    Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z50110509
    Klíčová slova: Chromosome territory * Gene expression * Confocal imaging
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.406, rok: 2011

    In this study we analyzed the position of the cell cycle regulator gene p21 within the CT of human chromosome 6 (HSA6) upon transcriptional activation. Whereas the majority of active p21 genes is located in the interior of the CT of HSA6, induction of p21 transcription correlates with increased variation of gene localization within the CT and with a higher percentage of p21 genes located at the periphery of the CT. Additionally it demonstrates once more that transcription can take place throughout CTs. Comparison of the p21 locus with two non-coding regions on HSA6 showed that both non-coding sequences are located more frequently in the interior of the CT than p21 genes although they are situated in chromosomal neighborhoods with widely differing gene density and regional transcriptional activity. Thus our data support models describing an influence of the transcriptional activity of a gene on the localization within its CT.
    Trvalý link: http://hdl.handle.net/11104/0194498
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