Počet záznamů: 1

Roles of conserved ectodomain cysteines of the rat P2X4 purinoreceptor in agonist binding and channel gating

  1. 1.
    0355715 - FGU-C 2011 RIV CZ eng J - Článek v odborném periodiku
    Rokic, Milos Boro - Tvrdoňová, Vendula - Vávra, Vojtěch - Jindřichová, Marie - Obšil, T. - Stojilkovic, S. S. - Zemková, Hana
    Roles of conserved ectodomain cysteines of the rat P2X4 purinoreceptor in agonist binding and channel gating.
    Physiological Research. Roč. 59, č. 6 (2010), s. 927-935 ISSN 0862-8408
    Grant CEP: GA AV ČR(CZ) IAA500110910; GA ČR(CZ) GA305/07/0681; GA MŠk(CZ) LC554
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: P2X4 receptor * ATP * disulfide bonds
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 1.646, rok: 2010

    Mammalian P2X receptors contain ten conserved cysteine residues in their ectodomains, which form five disulfide bonds. Replacement of cysteine pairs with threonines resulted in decreased sensitivity of P2X4 receptor to ATP. Three bonds contribute substantially to the structure of the ligand binding pocket, while the bond located towards the transmembrane domain contributes to receptor gating
    Trvalý link: http://hdl.handle.net/11104/0194417