Počet záznamů: 1

Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase

  1. 1.
    0355550 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Nůsková, Hana - Vrbacký, Marek - Drahota, Zdeněk - Houštěk, Josef
    Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase.
    Journal of Bioenergetics and Biomembranes. Roč. 42, č. 5 (2010), s. 395-403 ISSN 0145-479X
    Grant CEP: GA ČR(CZ) GA303/07/0781; GA MŠk(CZ) 1M0520; GA MŠk OC08017
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: cytochrom c oxidase * cyanide * oxygen affinity
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 3.637, rok: 2010

    Analysis of the mechanism of cyanide inhibitory effect on the mitochondrial cytochrome c oxidase demonstrates that the inhibition of COX by cyanide is fully reversible but the potential of pyruvate as a cyanide poisoning antidote is limited. COX affinity for oxygen is the most sensitive indicator of cyanide toxic effects
    Trvalý link: http://hdl.handle.net/11104/0194296