Počet záznamů: 1

Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats

  1. 1.
    0355370 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Bubeníková-Valešová, V. - Svoboda, Jan - Horáček, J. - Sumiyoshi, T.
    Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats.
    Psychopharmacology. Roč. 212, č. 2 (2010), s. 267-276 ISSN 0033-3158
    Grant CEP: GA MŠk(CZ) 1M0517
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: Tandospirone * Schizophrenia * NMDA receptor
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.817, rok: 2010

    These findings suggest that behavioural changes induced by tandospirone are not fully blocked by 5-HT1A antagonists and that tandospirone (5 mg/kg) potentiates the effect of MK-801. Overall, these findings point to an interaction between NMDA and 5-HT(1A) receptors. Part of the effect of tandospirone on locomotor activity may be mediated by the actions of its active metabolites on other neurotransmitter systems
    Trvalý link: http://hdl.handle.net/11104/0194155