Počet záznamů: 1

Interaction of glutamate- and adenosine-induced decrease of acetylcholine quantal release at frog neuromuscular junction

  1. 1.
    0355368 - FGU-C 2011 RIV CZ eng J - Článek v odborném periodiku
    Adámek, S. - Shakirzyanova, V. - Malomouzh, A. I. - Naumenko, N. V. - Vyskočil, František
    Interaction of glutamate- and adenosine-induced decrease of acetylcholine quantal release at frog neuromuscular junction.
    Physiological Research. Roč. 59, č. 5 (2010), s. 803-810 ISSN 0862-8408
    Grant CEP: GA AV ČR(CZ) IAA500110905; GA ČR GA202/09/0806
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: Endplate potentials * Guanylyl cyclase
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 1.646, rok: 2010

    The depression of nerve stimulation evoked number of quanta (EPC) by glutamate was removed by inhibition of the NO production in the muscle and the NO cascade is common post-receptor pathway started by both glutamate and adenosine presynaptic receptors. Spontaneously released quanta (MEPCs) are not regulated by NO cascade in the presence of glutamate and its specific effect on the evoked release points to modulation (phosphorylation) of the voltage-dependent Ca2+ channels at the release zone that are necessary for evoked quantal release during nerve stimulation
    Trvalý link: http://hdl.handle.net/11104/0194153