Počet záznamů: 1

Cytokines shape chemotherapy-induced and 'bystander' senescence

  1. 1.
    0353769 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Hodný, Zdeněk - Hubáčková, Soňa - Bartek, Jiří
    Cytokines shape chemotherapy-induced and 'bystander' senescence.
    Aging. Roč. 2, č. 2 (2010), s. 375-376 ISSN 1945-4589
    Grant CEP: GA ČR GA204/08/1418; GA ČR GA301/08/0353
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: bystander cellular senescence * cytokines * PML
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.964, rok: 2010

    In this short summary we discuss our recently published data about the newly emerging role of autocrine and paracrine cytokine signaling pathways in development of senescent phenotype in perspective of other data reported. DNA damage response activated by chronic subtoxic stresses leads to expression of cytokine encoding genes either primarily due to DNA damage activated kinases and/or secondarily through autocrine and paracrine effects of secreted cytokines, which activate network of cytokine-driven signaling pathways such as JAK/STAT. Changed gene expression pattern of senescent cells includes several tumor suppressors such as interferons, PML, STAT and IRF1. Intriguingly, persistent exposition of cells to conditioned media of chemotherapy-induced senescent cells is able to evoke premature senescence in neighbouring 'bystanding' cells.
    Trvalý link: http://hdl.handle.net/11104/0192921