Počet záznamů: 1

Bulky DNA adducts in white blood cells: a pooled analysis of 3600 subjects

  1. 1.
    0353745 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Ricceri, F. - Godschalk, R. W. - Peluso, M. - Philips, D. H. - Agudo, A. - Georgiadis, P. - Loft, S. - Tjonneland, A. - Raaschau-Nielsen, O. - Palli, D. - Perera, F. - Vermeulen, R. - Taioli, E. - Šrám, Radim - Munnia, A. - Rosa, F. - Allione, A. - Matullo, G. - Vineis, P.
    Bulky DNA adducts in white blood cells: a pooled analysis of 3600 subjects.
    Cancer Epidemiology Biomarkers & Prevention. Roč. 19, č. 12 (2010), s. 3174-3181 ISSN 1055-9965
    Grant ostatní: European Union ECNIS(XE) FOOD-CT-2005-513943
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: DNA adducts * biomarkers of exposure * air pollution
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 4.190, rok: 2010

    Eleven studies (3,600 subjects) were compared, in which bulky DNA adducts were measured in human white blood cells with similar 32P-postlabelling techniques and for which a similar set of variables was available (data on age, gender, ethnicity, smoking, season of blood collection and a limited set of gene variants). Only weak association between bulky DNA adducts and exposure variables was found. Seasonality (with higher adducts levels in winter) and air pollution may partly explain some of the inter-area differences (North vs. South Europe), but most inter-area and inter-individual variations in adduct levels still remain unexplained.
    Trvalý link: http://hdl.handle.net/11104/0192901