Počet záznamů: 1

Porcine insulin receptor substrate 4 (IRS4) gene: cloning, polymorphism and association study

  1. 1.
    0353420 - UZFG-Y 2012 RIV NL eng J - Článek v odborném periodiku
    Masopust, Martin - Vykoukalová, Z. - Knoll, Aleš - Bartenschlager, H. - Mileham, A. - Deeb, N. - Rohrer, G. A. - Čepica, Stanislav
    Porcine insulin receptor substrate 4 (IRS4) gene: cloning, polymorphism and association study.
    Molecular Biology Reports. Roč. 38, - (2010), 2611-2617 ISSN 0301-4851
    Grant CEP: GA ČR GA523/07/0353; GA ČR GAP502/10/1216
    Výzkumný záměr: CEZ:AV0Z50450515
    Klíčová slova: PCR cloning * Polymorphism * IRS4
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 1.875, rok: 2010

    Using PCR and inverse PCR techniques we obtained a 4,498 bp nucleotide sequence FN424076 encompassing the complete coding sequence of the porcine insulin receptor substrate 4 (IRS4) gene and its proximal promoter. The 1,269 amino acid porcine protein deduced from the nucleotide sequence shares 92% identity with the human IRS4 and possesses the same domains and the same number of tyrosine phosphorylation motifs as the human protein. We detected substitution FN424076:g.96C<G in the promoter region that segregates in Meishan and a synonymous substitution FN424076:g.1829T<C in the coding sequence with allele C present only in Meishan.
    Trvalý link: http://hdl.handle.net/11104/0192673
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