Počet záznamů: 1

Synthesis and Biochemical Characterization of a Series of 17alpha-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor alpha

  1. 1.
    0352926 - UOCHB-X 2011 RIV US eng J - Článek v odborném periodiku
    Eignerová, B. - Sedlák, David - Dračínský, Martin - Bartůněk, Petr - Kotora, Martin
    Synthesis and Biochemical Characterization of a Series of 17alpha-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor alpha.
    Journal of Medicinal Chemistry. Roč. 53, č. 19 (2010), s. 6947-6953 ISSN 0022-2623
    Grant CEP: GA MŠk(CZ) LC06077; GA AV ČR IAA400550609
    Grant ostatní:GA MŠk(CZ) LC06070
    Program:LC
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50520514
    Klíčová slova: estrogen receptor * estradiols * selective ligands
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 5.207, rok: 2010

    Synthesis of a new class of potent and selective ligands for estrogen receptor alpha represented by a series of 17alpha-substituted estradiolsbearing lipophilic perfluoroalkyl chains.These estradiols were synthetized by Ru-catalyzed cross metathesis reactions.
    Trvalý link: http://hdl.handle.net/11104/0192310