Počet záznamů: 1

Diastereoselective reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl) -propyl]-4 (S)-(4-hydroxyphenyl)azetidin-2-one to Ezetimibe by the whole cell catalyst Rhodococcus fascians MO22

  1. 1.
    0352907 - MBU-M 2011 RIV NL eng J - Článek v odborném periodiku
    Kyslíková, Eva - Babiak, P. - Marešová, Helena - Palyzová, Andrea - Hajíček, J. - Kyslík, Pavel
    Diastereoselective reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl) -propyl]-4 (S)-(4-hydroxyphenyl)azetidin-2-one to Ezetimibe by the whole cell catalyst Rhodococcus fascians MO22.
    Journal of Molecular Catalysis B-Enzymatic. Roč. 67, 3-4 (2010), s. 266-270 ISSN 1381-1177
    Grant CEP: GA MŠk 2B08064
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Biotransformation * Rhodococcus fascians MO22 * Ezetimibe
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.330, rok: 2010

    Catalytic capability of Rhodococcus fascians MO22 for reduction has been examined with ketone and protected ketone, an intermediate from chemical synthesis of Ezetimibe. Various parameters of the bioreduction have been optimized: the strain converted 94.8 percent of ketone and 63 percent of protected ketone into Ezetimibe with the same de of 99.9 percent. In the later case, two chemical steps are replaced with a single biotransformation
    Trvalý link: http://hdl.handle.net/11104/0192295