Počet záznamů: 1

Structure of the catalytic domain of the human mitochondrial Lon protease: Proposed relation of oligomer formation and activity

  1. 1.
    0352899 - MBU-M 2011 RIV US eng J - Článek v odborném periodiku
    García-Nafría, J. - Ondrovičová, G. - Blagova, E. - Levdikov, V. M. - Bauer, J. A. - Suzuki, C. K. - Kutejová, Eva - Wilkinson, A. J. - Wilson, K. S.
    Structure of the catalytic domain of the human mitochondrial Lon protease: Proposed relation of oligomer formation and activity.
    Protein Science. Roč. 19, č. 5 (2010), s. 987-999 ISSN 0961-8368
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: ATP-dependent protease * Lon protease * catalytic dyad
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.741, rok: 2010

    ATP-dependent proteases are crucial for cellular homeostasis. By degrading short-lived regulatory proteins, they play an important role in the control of many cellular pathways and, through the degradation of abnormally misfolded proteins, protect the cell from a buildup of aggregates. Disruption or disregulation of mammalian mitochondrial Lon protease leads to severe changes in the cell, linked with carcinogenesis, apoptosis, and necrosis
    Trvalý link: http://hdl.handle.net/11104/0192290