Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy

0352737 - ÚEB 2011 RIV DE eng P - Patentový dokument
Moravcová, Daniela - Havlíček, Libor - Kryštof, Vladimír - Lenobel, René - Strnad, Miroslav
Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy.
Mnichov: The European Patent Office (EPO), 2010. Vlastník: Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci. Datum podání přihlášky: 28.03.2002. Datum udělení patentu: 25.08.2010. Číslo patentu: EP1348707
Grant CEP: GA ČR GA301/08/1649; GA ČR GA522/09/1576
Klíčová slova: Pyrazolo[4,3-D]pyrimidines * processes * preparation * methods * therapy
Kód oboru RIV: FD - Onkologie a hematologie
http://v3.espacenet.com/publicationDetails/originalDocument?FT=D&date=20100825&DB=EPODOC&locale=en_EP&CC=EP&NR=1348707B1&KC=B1 http://arl-repository.lib.cas.cz/uloziste_av/UEB-Q/cav_un_epca-0352737_01.pdf

The invention relates to new pyrazolo (4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. It is an object of this invention to provide anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds having improved selectivity and efficiency index, i. E. that are less toxic yet more efficacious tha analogues known heretofore. It is an object of this invention to provide 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide pharmaceutical composition, which comprises a 3,5,7-ftrisubstituted pyrazolo(4,3-d)pyrimidine and a pharmaceutically acceptable carrier.
Trvalý link: http://hdl.handle.net/11104/0192181