Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia

0351994 - BTÚ 2011 RIV US eng J - Článek v odborném periodiku
Bohuslavová, Romana - Kolář, František - Kuthanová, Lada - Neckář, Jan - Tichopád, Aleš - Pavlínková, Gabriela
Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia.
Journal of Applied Physiology. Roč. 109, č. 4 (2010), s. 1195-1202. ISSN 8750-7587. E-ISSN 1522-1601
Grant CEP: GA ČR GA301/09/0117
Výzkumný záměr: CEZ:AV0Z50520701; CEZ:AV0Z50110509
Klíčová slova: Hypoxia inducible factor 1 alpha * hypoxia * gene expression profiling
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.232, rok: 2010

Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. We hypothesize that adaptive responses to chronic hypoxia are the result of altered transcriptional regulations in the right and left ventricles. Here we report results from the gene expression profiling of adaptive responses in a chronically hypoxic heart. Of 11 analyzed candidate genes, the expression of seven and four genes, respectively, was significantly altered in the right ventricle of hypoxic male and female mice. In the transcriptional profile of the left ventricle, we identified a single expression change in hypoxic males (Vegfa gene). To directly test the role of HIF1, we analyzed the expression profile in Hif1a partially deficient mice exposed to moderate hypoxia
Trvalý link: http://hdl.handle.net/11104/0191609