Počet záznamů: 1

Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia

  1. 1.
    0351994 - BTO-N 2011 RIV US eng J - Článek v odborném periodiku
    Bohuslavová, Romana - Kolář, František - Kuthanová, Lada - Neckář, Jan - Tichopád, Aleš - Pavlínková, Gabriela
    Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia.
    Journal of Applied Physiology. Roč. 109, č. 4 (2010), s. 1195-1202 ISSN 8750-7587
    Grant CEP: GA ČR GA301/09/0117
    Výzkumný záměr: CEZ:AV0Z50520701; CEZ:AV0Z50110509
    Klíčová slova: Hypoxia inducible factor 1 alpha * hypoxia * gene expression profiling
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.232, rok: 2010

    Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. We hypothesize that adaptive responses to chronic hypoxia are the result of altered transcriptional regulations in the right and left ventricles. Here we report results from the gene expression profiling of adaptive responses in a chronically hypoxic heart. Of 11 analyzed candidate genes, the expression of seven and four genes, respectively, was significantly altered in the right ventricle of hypoxic male and female mice. In the transcriptional profile of the left ventricle, we identified a single expression change in hypoxic males (Vegfa gene). To directly test the role of HIF1, we analyzed the expression profile in Hif1a partially deficient mice exposed to moderate hypoxia
    Trvalý link: http://hdl.handle.net/11104/0191609
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