Počet záznamů: 1

Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes

  1. 1.
    0351889 - UT-L 2011 RIV SE eng J - Článek v odborném periodiku
    Bébarová, M. - Matejovič, P. - Pásek, Michal - Ohlídalová, D. - Jansová, D. - Šimurdová, M. - Šimurda, J.
    Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes.
    Acta Physiologica. Roč. 200, č. 4 (2010), s. 301-314 ISSN 1748-1708
    Výzkumný záměr: CEZ:AV0Z20760514
    Klíčová slova: action potential * ethanol * rat ventricular myocyte
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.138, rok: 2010
    http://apps.isiknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=15&SID=Y1pmpi@7k2HPEc8ehEE&page=1&doc=1&colname=WOS

    Ethanol belongs to the group of agents that significantly affect the function of cardiac myocytes. The results of performed experiments showed that ethanol reversibly decelerates the upstroke velocity of action potential and decreases its amplitude and duration. Further exploration of the effect of ethanol on membrane ionic currents showed, that ethanol efficiently suppresses INa, ICa and Ito with 50% inhibition at 446 mM, 553 mM a 1954 mM, respectively.
    Trvalý link: http://hdl.handle.net/11104/0191533