Počet záznamů: 1

Effect of newly synthesized compounds 44Bu and 444 on QRS -complex width and fast sodium current

  1. 1.
    0351888 - UT-L 2011 RIV CZ eng J - Článek v odborném periodiku
    Kilianová, A. - Bébarová, M. - Beránková, K. - Opatřilová, R. - Pásek, Michal - Bartošová, L.
    Effect of newly synthesized compounds 44Bu and 444 on QRS -complex width and fast sodium current.
    Acta veterinaria Brno. Roč. 79, č. 1 (2010), s. 41-49 ISSN 0001-7213
    Výzkumný záměr: CEZ:AV0Z20760514
    Klíčová slova: 444 * 44Bu * QRS-complex * sodium current * rat
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 0.534, rok: 2010

    In this study, we explored the effect of both racemates and particular isomers of 44Bu and 444 on the QRS-complex width in vivo in rats and on INa in isolated rat ventricular myocytes. All variants of 44Bu and 444 (1.5 mg/kg) caused a significant QRS-widening reaching the peak effect at the 1st or 2nd min after their intravenous administration. 44Bu racemate widened the QRS-complex by 57%, significantly more than R- (33%-widening) and S-isomer (36%-widening). 444 racemate widened the QRS-complex by 64%, which was comparable to S-isomer (63%-widening), however, substantially more than R-isomer (40%-widening). Regarding the effect on INa, 44Bu caused a significantly deeper INa-block compared to 444 in the same concentration of 3.0 micromol/l (0.1 mg/kg). 44Bu racemate and R-isomer blocked INa similarly (91.7 and 91.8%-block, respectively), significantly more than S-isomer (82.4%-block). 444 R-isomer blocked INa less than racemate and S-isomer (by 31.7% vs. 48.3 and 50.2%, respectively).
    Trvalý link: http://hdl.handle.net/11104/0191532