Počet záznamů: 1

Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation

  1. 1.
    0351847 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Rampichová, Michala - Filová, Eva - Varga, F. - Lytvynets, Andriy - Prosecká, Eva - Koláčná, Lucie - Motlík, Jan - Nečas, A. - Vajner, L. - Uhlík, J. - Amler, Evžen
    Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation.
    Asaio Journal. Roč. 56, č. 6 (2010), s. 563-568 ISSN 1058-2916
    Grant CEP: GA ČR GAP304/10/1307
    Grant ostatní: GA MŠk(CZ) 2B06130; GA ČR.(CZ) GA202/09/1151; EU(XE) BIOSCENT ID214539; GA UK(CZ) 119209
    Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50390703; CEZ:AV0Z50450515
    Klíčová slova: chondrocyte * composite scaffold * osteochondral defect regeneration
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 1.221, rok: 2010

    Hydrogels prepared from a mixture of fibrin and high-molecular weight (MW) hyaluronic acid (HA) were found to be suitable scaffolds for chondrocyte seeding and pig knee cartilage regeneration. Collagen in the hydrogels is not necessary for the formation of biomechanically stable tissue. Regenerated cartilage showed very good biomechanical and histological properties only 6 months after implantation. Notably, the quality of the healing process was dependent on the initial chondrocyte concentration of the scaffolds. These experiments were performed according to good laboratory practice (GLP).
    Trvalý link: http://hdl.handle.net/11104/0191503