Actin complexes in the cell nucleus: new stones in an old field

0351361 - ÚMG 2011 RIV DE eng J - Článek v odborném periodiku
Castano, Enrique - Philimonenko, Vlada - Kahle, Michal - Fukalová, Jana - Kalendová, Alžběta - Yildirim, Sukriye - Dzijak, Rastislav - Dingová, Hana - Hozák, Pavel
Actin complexes in the cell nucleus: new stones in an old field.
Histochemistry and Cell Biology. Roč. 133, č. 6 (2010), s. 607-626. ISSN 0948-6143. E-ISSN 1432-119X
Grant CEP: GA ČR(CZ) GA204/07/1592; GA ČR(CZ) GD204/09/H084; GA MŠMT LC545; GA MŠMT 2B06063
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: RNA polymerase II * ABL tyrosine kinase * F-actin
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.727, rok: 2010

Actin is a well-known protein that has shown a myriad of activities in the cytoplasm. However, recent findings of actin involvement in nuclear processes are overwhelming. Actin complexes in the nucleus range from very dynamic chromatin-remodeling complexes to structural elements of the matrix with single partners known as actin-binding proteins (ABPs). This review summarizes the recent findings of actin-containing complexes in the nucleus. Particular attention is given to key processes like chromatin remodeling, transcription, DNA replication, nucleocytoplasmic transport and to actin roles in nuclear architecture. Understanding the mechanisms involving ABPs will definitely lead us to the principles of the regulation of gene expression performed via concerting nuclear and cytoplasmic processes.
Trvalý link: http://hdl.handle.net/11104/0191131