Počet záznamů: 1

Actin complexes in the cell nucleus: new stones in an old field

  1. 1.
    0351361 - UMG-J 2011 RIV DE eng J - Článek v odborném periodiku
    Castano, Enrique - Philimonenko, Vlada - Kahle, Michal - Fukalová, Jana - Kalendová, Alžběta - Yildirim, Sukriye - Dzijak, Rastislav - Dingová, Hana - Hozák, Pavel
    Actin complexes in the cell nucleus: new stones in an old field.
    Histochemistry and Cell Biology. Roč. 133, č. 6 (2010), s. 607-626 ISSN 0948-6143
    Grant CEP: GA ČR(CZ) GA204/07/1592; GA ČR(CZ) GD204/09/H084; GA MŠk LC545; GA MŠk 2B06063
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: RNA polymerase II * ABL tyrosine kinase * F-actin
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.727, rok: 2010

    Actin is a well-known protein that has shown a myriad of activities in the cytoplasm. However, recent findings of actin involvement in nuclear processes are overwhelming. Actin complexes in the nucleus range from very dynamic chromatin-remodeling complexes to structural elements of the matrix with single partners known as actin-binding proteins (ABPs). This review summarizes the recent findings of actin-containing complexes in the nucleus. Particular attention is given to key processes like chromatin remodeling, transcription, DNA replication, nucleocytoplasmic transport and to actin roles in nuclear architecture. Understanding the mechanisms involving ABPs will definitely lead us to the principles of the regulation of gene expression performed via concerting nuclear and cytoplasmic processes.
    Trvalý link: http://hdl.handle.net/11104/0191131