Počet záznamů: 1

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

  1. 1.
    0351336 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Sousa, K.M. - Villaescusa, J.C. - Čajánek, L. - Ondr, J.K. - Castelo-Branco, G. - Hofstra, W. - Bryja, Vítězslav - Palmberg, C. - Bergman, T. - Wainwright, B. - Lang, R.A. - Arenas, E.
    Wnt2 regulates progenitor proliferation in the developing ventral midbrain.
    Journal of Biological Chemistry. Roč. 285, č. 10 (2010), s. 7246-7253 ISSN 0021-9258
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: Wnt2 * ventral midbrain * dopaminergic neuron
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 5.328, rok: 2010

    In this study, we perform the first purification and signaling analysis of Wnt2 and define the function of Wnt2 in ventral midbrain precursor cultures, as well as in Wnt2-null mice in vivo. Collectively, our observations identify Wnt2 as a novel regulator of dopaminergic progenitors and dopaminergic neuron development.
    Trvalý link: http://hdl.handle.net/11104/0191111