Počet záznamů: 1

Synthetic polymer-drug conjugates for human therapy

  1. 1.
    0351235 - UMCH-V 2011 RIV SG eng M - Část monografie knihy
    Ulbrich, Karel - Šubr, Vladimír
    Synthetic polymer-drug conjugates for human therapy.
    Handbook of Materials for Nanomedicine. Singapore: Pan Stanford Publishing Pte Ltd, 2010 - (Torchilin, V.; Amiji, M.), s. 5-79. ISBN 978-981-4267-55-7
    Grant CEP: GA AV ČR IAAX00500803
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: drug delivery * polymer-drug conjugates * drug targeting
    Kód oboru RIV: CD - Makromolekulární chemie

    Polymer-drug conjugates represent a novel generation of polymer therapeutics enabling site-specific drug action what predestines them predominantly for tumor therapy. In this review a design, synthesis and physico-chemical and biological properties of water-soluble synthetic polymer-drug conjugates including principles of tumor-specific passive and tumor cell-specific active targeting, controlled drug release and elimination of the polymer drug carrier from organism is discussed and potential of polymer-drug conjugates for tumor treatment is evaluated.
    Trvalý link: http://hdl.handle.net/11104/0191032