Počet záznamů: 1

Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2

  1. 1.
    0351205 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Witte, F. - Bernatík, O. - Kirchner, K. - Mašek, J. - Mahl, A. - Krejčí, P. - Mundlos, S. - Schambony, A. - Bryja, Vítězslav - Stricker, S.
    Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.
    FASEB Journal. Roč. 24, č. 7 (2010), s. 2417-2426 ISSN 0892-6638
    Grant CEP: GA ČR(CZ) GC204/09/J030
    Grant ostatní:GA AV ČR(CZ) KJB501630801; GA ČR(CZ) GD204/09/H058; GA ČR(CZ) GA204/09/0498
    Program:GD
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: Wnt/beta-catenin signaling * casein kinase * Ror2
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 6.515, rok: 2010

    Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.
    Trvalý link: http://hdl.handle.net/11104/0191007