Počet záznamů: 1

Glycosylation protects proteins against free radicals generated from toxic xenobiotics

  1. 1.
    0350771 - MBU-M 2011 RIV US eng J - Článek v odborném periodiku
    Martínek, V. - Sklenář, Jan - Dračínský, Martin - Šulc, M. - Hofbauerová, Kateřina - Bezouška, K. - Frei, E. - Stiborová, M.
    Glycosylation protects proteins against free radicals generated from toxic xenobiotics.
    Toxicological Sciences. Roč. 117, č. 2 (2010), s. 359-374 ISSN 1096-6080
    Grant CEP: GA MŠk 1M0505; GA ČR GA303/09/0477
    Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z40550506
    Klíčová slova: hrp * sudan I * ellipticine
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 5.093, rok: 2010

    Free radicals generated during peroxidase-catalyzed oxidation of two xenobiotics, carcinogenic Sudan I and an anticancer agent ellipticine, easily attack unmodified proteins but not glycoproteins. A significant inverse correlation between the extent of glycosylation of proteins and the degree of binding of Sudan I or ellipticine radicals to these proteins was observed, whereby the protection only occurs if oligosaccharides are covalently bound to the proteins
    Trvalý link: http://hdl.handle.net/11104/0190681