Počet záznamů: 1

Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes

  1. 1.
    0350431 - UEM-P 2011 RIV DE eng J - Článek v odborném periodiku
    Palygin, O. - Lalo, U. - Verkhratsky, Alexei - Pankratov, Y.
    Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes.
    Cell Calcium. Roč. 48, č. 4 (2010), s. 225-231 ISSN 0143-4160
    Grant CEP: GA ČR GA305/08/1384
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: Astroglia * Ca2+ signalling * NMDA receptors
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.553, rok: 2010

    These results demonstrate that activation of astroglial ionotropic NMDA and P2X1/5 receptors increases intracellular free calcium in cortical astrocytes when stimulated by endogenous agonists and synaptic release of neurotransmitters. These data suggest contribution of NMDA and P2X1/5 receptors to astroglial calcium signalling, which may provide a specific mechanism for fast neuronal-glial signalling at the synaptic level.
    Trvalý link: http://hdl.handle.net/11104/0190443