Počet záznamů: 1

CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis

  1. 1.
    0350375 - MBU-M 2011 RIV US eng J - Článek v odborném periodiku
    Richter, Jan - Benson, Veronika - Grobárová, Valeria - Svoboda, Jan - Vencovský, J. - Svobodová, R. - Fišerová, Anna
    CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis.
    Clinical Immunology. Roč. 136, č. 1 (2010), s. 139-147 ISSN 1521-6616
    Grant CEP: GA ČR GA310/06/0477; GA ČR GD310/08/H077; GA MZd NR9106; GA AV ČR IAA500200620
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Rheumatoid arthritis * NK cells * CD161
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 3.932, rok: 2010

    High levels of CD161 receptor of NK cells are correlated with impairment of NK cytotoxic activity in RA patients. We propose that MCV plays an important role in RA by increasing expression of CD161, which leads to inhibition of NK cell activity and, consequently, insufficient downregulation of autoreactive T cell, thus accelerating disease progression
    Trvalý link: http://hdl.handle.net/11104/0190392