Počet záznamů: 1

Glycosylation regulates NK cell-mediated effector function through PI3K pathway

  1. 1.
    0350365 - MBU-M 2011 RIV GB eng J - Článek v odborném periodiku
    Benson, Veronika - Grobárová, Valeria - Richter, Jan - Fišerová, Anna
    Glycosylation regulates NK cell-mediated effector function through PI3K pathway.
    International Immunology. Roč. 22, č. 3 (2010), s. 167-177 ISSN 0953-8178
    Grant CEP: GA AV ČR IAA500200620; GA AV ČR IAA500200509; GA ČR GA204/06/0771; GA ČR GD310/08/H077
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: cytotoxic activity * gene regulation * glycoconjugate
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 3.301, rok: 2010

    The modulation of glycosyltransferases MGAT3 and MGAT5 by chemically defined synthetic GCGN4C correlated with the improvement of NK cell effector functions and the augmentation of tumor cell sensitivity to NK cell-mediated cytotoxicity. These results demostrate the great potential of the GN4C compound as a NK cell-mediated antitumor response modulator
    Trvalý link: http://hdl.handle.net/11104/0190384