Počet záznamů: 1

HPMA – Anticancer Drug Conjugates

  1. 1.
    0350338 - MBU-M 2011 RIV US eng M - Část monografie knihy
    Říhová, Blanka - Hovorka, Ondřej - Kovář, Lubomír - Kovář, Marek - Mrkvan, Tomáš - Šírová, Milada - Šubr, Vladimír - Ulbrich, Karel
    HPMA – Anticancer Drug Conjugates.
    Macromolecular Anticancer Therapeutics. New York: Springer, 2010 - (Reddy, L.; Couvreur, P.), s. 87-132. ISBN 978-1-4419-0506-2
    Grant CEP: GA AV ČR KAN200200651; GA AV ČR IAAX00500803; GA MŠk 1M0505
    Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z40500505
    Klíčová slova: hpma * doxorubicin * cytotoxicity
    Kód oboru RIV: EC - Imunologie

    Homopolymer poly(HPMA) was originally developed as a blood expander “Duxon.” Later on, linear Nondegradable HPMA copolymer of a molecular weight 25kDa was used as the backbone to which drugs, mostly doxorubicin, were attached through different side chains and different covalent bonds. Non-targeted and targeted polymer–drug derivatives based on HPMA have both cytostatic and immunostimulating activity. Their impressive anti-tumor effects most likely result from the combination of strong direct cytotoxicity and a systemic anticancer resistance regularly induced during the treatment
    Trvalý link: http://hdl.handle.net/11104/0190365