Počet záznamů: 1

Calreticulin is a B cell molecular target in some gastrointestinal malignancies

  1. 1.
    0350328 - MBU-M 2011 RIV GB eng J - Článek v odborném periodiku
    Pekáriková, Aneta - Sánchez, Daniel - Palová-Jelínková, Lenka - Šimšová, Marcela - Beneš, Z. - Hoffmanová, I. - Drastich, P. - Janatková, I. - Mothes, T. - Tlaskalová-Hogenová, Helena - Tučková, Ludmila
    Calreticulin is a B cell molecular target in some gastrointestinal malignancies.
    Clinical and Experimental Immunology. Roč. 160, č. 2 (2010), s. 215-222 ISSN 0009-9104
    Grant CEP: GA AV ČR IAA500200709; GA AV ČR IAA500200801; GA ČR GD310/08/H077; GA ČR GA310/07/0414; GA MŠk 2B06155
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: antigenic epitopes * autoantibodies * calreticulin
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 3.134, rok: 2010

    Using enzyme-linked immunosorbent assay (ELISA) , we found immunoglobulin (Ig)A and/or IgG anti-calreticulin antibodies in sera of approximately 63 of patients with hepatocellular carcinoma, 57 of patients with colorectal adenocarcinoma (CRA) and 47% of patients with pancreatic adenocarcinoma (PACA), while healthy controls, patients with viral hepatitis C and with chronic pancreatitis reached only 2, 20 abd 31 seropositivity, respectively. Pepscan analysis revealed a large number of antigenic epitopes of calreticulin recognized by both IgA and IgG antibodies of patients with HCC and PACA, indicating robust systemic immune response
    Trvalý link: http://hdl.handle.net/11104/0190357