Počet záznamů: 1

A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms

  1. 1.
    0350230 - MBU-M 2011 RIV GB eng J - Článek v odborném periodiku
    D'Antona, N. - Morrone, R. - Bovicelli, P. - Gambera, G. - Kubáč, David - Martínková, Ludmila
    A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms.
    Tetrahedron Asymmetry. Roč. 21, č. 20 (2010), s. 2448-2454 ISSN 0957-4166
    Grant CEP: GA MŠk OC09046
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: BETA-GLUCOSIDASE INHIBITOR * FACILE SYNTHESES * CYCLOPHELLITOL
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.484, rok: 2010

    A new route to synthesize cyclophellitol and epi-cyclophellitol from racemic starting materials in enantiopure forms has been developed. The synthesis involves a multi-enzymatic biotransformation pathway of the novel cyano-cyclitol (1R,4S,5R,6R)/(1S,4R,5S,6S)-4,5,6-trihydroxycyclohex-2-enecarbonitrile by a cooperative use of lipase, nitrile hydratase, and amidase
    Trvalý link: http://hdl.handle.net/11104/0190283