Počet záznamů: 1

Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.

  1. 1.
    0350189 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Evans, M. D. - Olinski, R. - Loft, M. S. - Rössner ml., Pavel - Šrám, Radim
    Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.
    FASEB Journal. Roč. 24, č. 4 (2010), s. 1249-1260 ISSN 0892-6638
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: DNA damage * DNA repair * immunoassay
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 6.515, rok: 2010

    The manuscript compares chromatographic and immunoassay methods used for the detection of urinary 8-oxo-7,8-dihydro-2‘-deoxyguanosine (8-oxodG). Samples containing different concentrations of 8-oxodG were sent to ESCULA members. Data were returned from 17 laboratories, representing 20 detection methods. There was good within-technique agreement for most of the laboratories. ELISA, however, showed more within-technique variation and reported higher 8-oxodG values. Overall, the study reveals greater consensus than previously expected, although some concern remains over ELISA.
    Trvalý link: http://hdl.handle.net/11104/0190256