Počet záznamů: 1

Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide

  1. 1.
    0350075 - UEM-P 2011 RIV IT eng J - Článek v odborném periodiku
    Kmoníčková, Eva - Harmatha, Juraj - Vokáč, Karel - Kostecká, Petra - Farghali, H. - Zídek, Zdeněk
    Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide.
    Fitoterapia. Roč. 81, č. 8 (2010), s. 1213-1219 ISSN 0367-326X
    Grant CEP: GA ČR GA305/07/0061
    Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z40550506
    Klíčová slova: trilobolide * nitric oxide * sesquiterpene lactones
    Kód oboru RIV: FR - Farmakologie a lékárnická chemie
    Impakt faktor: 1.899, rok: 2010

    Trilobolide (TB), a sesquiterpene lactone isolated from Laser trilobum is an inhibitor of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA). We have found that upon the in vitro exposure to TB, rodent peritoneal cells and human peripheral blood mononuclear cells secrete high amounts of IFN-γ. The effect is associated with the stimulation of high output NO biosynthesis in rat cells. The effect does not seem to depend on enhanced intracellular calcium levels.
    Trvalý link: http://hdl.handle.net/11104/0190168