Počet záznamů: 1

Alpha-cyclodextrins reversibly capped with disulfide bonds

  1. 1.
    0350020 - UOCHB-X 2011 RIV GB eng J - Článek v odborném periodiku
    Kumprecht, Lukáš - Buděšínský, Miloš - Bouř, Petr - Kraus, Tomáš
    Alpha-cyclodextrins reversibly capped with disulfide bonds.
    New Journal of Chemistry. Roč. 34, č. 10 (2010), s. 2254-2260 ISSN 1144-0546
    Grant CEP: GA AV ČR IAA400550810
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: cyclodextrins * disulfide bond * dynamic covalent bond
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.631, rok: 2010

    Per-O-methyl-6I, 6IV-disulfanyl-6I, 6IV-dideoxy-alpha-cyclodextrin undergoes air-oxidation at pH 9 to exclusively form monomeric species having an intramolecular disulfide linkage capping the C6I and C6IV positions. Molecular models show that the disulfide bridge effectively closes the primary rim of the the cyclodextrin cavity and can be cleaved by reduction with dithiothreitol. Thus, the macrocyclic system can interchange the open-ended and cup-like forms by application of external stimuli.
    Trvalý link: http://hdl.handle.net/11104/0190124