Počet záznamů: 1

Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites

  1. 1.
    0349909 - BU-J 2011 RIV GB eng J - Článek v odborném periodiku
    Zounková, R. - Kovalová, L. - Bláha, Luděk - Dott, W.
    Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites.
    Chemosphere. Roč. 81, č. 2 (2010), s. 253-260 ISSN 0045-6535
    Výzkumný záměr: CEZ:AV0Z60050516
    Klíčová slova: cytotoxic drugs * ecotoxicity * metabolite
    Kód oboru RIV: EF - Botanika
    Impakt faktor: 3.155, rok: 2010

    The present study investigated ecotoxicity and genotoxicity of three widely used cytostatic agents 5-fluorouracil (5-FU), cytarabine (CYT) and gemcitabine (GemC) and their major human metabolites, i.e. a-fluoro-b-alanine (FBAL), uracil-1-b-D-arabinofuranoside (AraU) and 20,20-difluorodeoxyuridine (dFdU), respectively. The effects were tested in a series of ecotoxicological assays including algae, invertebrates and bacteria. Novel information for the risk assessment of these compounds were derived.
    Trvalý link: http://hdl.handle.net/11104/0190035