Počet záznamů: 1

LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic

  1. 1.
    0349854 - UMG-J 2011 RIV GB eng J - Článek v odborném periodiku
    Hořejší, Václav - Otáhal, Pavel - Brdička, Tomáš
    LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic.
    FEBS Journal. Roč. 277, č. 21 (2010), s. 4383-4397 ISSN 1742-464X
    Grant CEP: GA ČR GEMEM/09/E011; GA MŠk 1M0506
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: LAT * transmembrane adaptor protein * membrane rafts
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.129, rok: 2010

    Membrane rafts are microdomains involved in a number of biologically important processes, including immunoreceptor signalling. Among the functionally important protein components of these microdomains are transmembrane adaptor proteins, containing in their intracellular domains tyrosine residues that can be phosphorylated and bind other cytoplasmic signalling proteins. The most important leukocyte transmembrane adaptor protein is LAT (linker for activation of T cells), which is critically involved in T cell receptor signalling, but also plays important roles in signal initiation by several other immunologically important receptors. Here we review recent progress in the elucidation of several aspects of this protein, e.g. the controversy concerning the importance of LAT being present in membrane rafts, the involvement in signalling through a number of receptors other than the T cell receptor and the puzzling phenotype of some LAT mutants.
    Trvalý link: http://hdl.handle.net/11104/0189989