Počet záznamů: 1

Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use

  1. 1.
    0349828 - UEB-Q 2011 RIV DE eng P - Patentový dokument
    Moravcová, Daniela - Havlíček, Libor - Kryštof, Vladimír - Lenobel, René - Binarová, Pavla - Mlejnek, P. - Vojtešek, B. - Uldrijan, S. - Schmülling, T. - Strnad, Miroslav
    Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use.
    Mnichov: European patent office, 2010. Vlastník: Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci. Datum podání přihlášky: 06.05.2003. Datum udělení patentu: 28.07.2010. Číslo patentu: EP1475094
    Grant CEP: GA ČR GA301/08/1649; GA ČR GA522/09/1576
    Klíčová slova: disubstituted pyrazolo[4,3-d]pyrimidine * cancer therapy * agricultural practice
    Kód oboru RIV: FD - Onkologie a hematologie
    http://v3.espacenet.com/publicationDetails/originalDocument?FT=D&date=20100728&DB=EPODOC&locale=en_EP&CC=EP&NR=1475094B1&KC=B1

    This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solution of this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
    Trvalý link: http://hdl.handle.net/11104/0189968