Počet záznamů: 1

Anticancer activity of natural cytokinins: A structure-activity relationship study

  1. 1.
    0349823 - UEB-Q 2011 RIV GB eng J - Článek v odborném periodiku
    Voller, Jiří - Zatloukal, Marek - Lenobel, René - Doležal, Karel - Béres, Tibor - Kryštof, Vladimír - Spíchal, Lukáš - Niemann, P. - Džubák, P. - Hajdúch, M. - Strnad, Miroslav
    Anticancer activity of natural cytokinins: A structure-activity relationship study.
    Phytochemistry. Roč. 41, 11-12 (2010), s. 1350-1359 ISSN 0031-9422
    Grant CEP: GA ČR GA301/08/1649; GA ČR GA206/09/1284
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: SAR * Cytokinins * Cancer
    Kód oboru RIV: FD - Onkologie a hematologie
    Impakt faktor: 3.150, rok: 2010

    This study presents the first analysis of relationship between chemical structure of cytokinins and their cytotoxic effects against a panel of human cancer cell lines with diverse histopatothological origin. The results confirm the cytotoxic activity of N6-isopentenyladenosine, kinetin riboside, and N6-benzyladenosine and show that the spectrum of cell lines that are sensitive to these compounds is wider than previously reported. The first evidence that the hydroxylated aromatic cytokinins and cis-zeatin riboside have cytotoxic activities is presented. Most cell lines showed greatest sensitivity to ortho-topolin riboside. Cytokinin nucleotides were usually active in a similar concentration range to the corresponding ribosides. However, cytokinin free bases, 2-methylthio derivatives and glucosides showed little or no toxicity. The study shows that structural requirements for cytotoxic activity of cytokinins against human cancer cell lines differ from their activity in plant bioassays.
    Trvalý link: http://hdl.handle.net/11104/0189963