Počet záznamů: 1

X-ray structure, NMR and stability-in-solution study of 6-(furfurylamino)-9-(tetrahydropyran-2-yl)purine - A new active compound for cosmetology

  1. 1.
    0349821 - UEB-Q 2011 RIV NL eng J - Článek v odborném periodiku
    Walla, Jan - Szüčová, Lucie - Císařová, I. - Gucký, Tomáš - Zatloukal, Marek - Doležal, Karel - Greplová, Jarmila - Massino, F.J. - Strnad, Miroslav
    X-ray structure, NMR and stability-in-solution study of 6-(furfurylamino)-9-(tetrahydropyran-2-yl)purine - A new active compound for cosmetology.
    Journal of Molecular Structure. Roč. 975, 1-3 (2010), s. 376-380 ISSN 0022-2860
    Grant CEP: GA ČR GA522/09/1576
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: Kinetin derivative * X-ray structure analysis * Cytokinin
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 1.599, rok: 2010

    The crystal and molecular structure of 6-(furfurylamino)-9-(tetrahydropyran-2-yl)purine (1) was determined at 150(2) K. The compound crystallizes in monoclinic P2(1)/c space group with a = 10.5642(2), = 13.6174(3), c = 10.3742(2) angstrom, V = 1460.78(5) angstrom(3), Z = 4, R(F) = for 3344 unique reflections. The purine moiety and furfuryl ring are planar and the tetrahydropyran-2-yl is disordered in the ratio 1:3, probably due to the chiral carbon atom C(17). The individual H-1 and C-13 NMR signals were assigned by 20 correlation experiments such as H-1-H-1 COSY and ge-2D HSQC. Stability-in-solution was determined in methanol/water in acidic pH (3-7).
    Trvalý link: http://hdl.handle.net/11104/0006114