Počet záznamů: 1

AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

  1. 1.
    0349619 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Jeleník, Tomáš - Rossmeisl, Martin - Kuda, Ondřej - Macek Jílková, Zuzana - Medříková, Daša - Kůs, Vladimír - Hensler, Michal - Janovská, Petra - Mikšík, Ivan - Baranowski, M. - Gorski, J. - Hébrard, S. - Jensen, T. E. - Flachs, Pavel - Hawley, S. - Viollet, B. - Kopecký, Jan
    AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids.
    Diabetes. Roč. 59, č. 11 (2010), s. 2737-2746 ISSN 0012-1797
    Grant CEP: GA ČR GAP301/10/1420; GA MŠk(CZ) 1M0520; GA MŠk(CZ) OC08007
    Grant ostatní:EC(CZ) LSHM-CT-2004-005272
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: AMPK * n-3 LC-PUFA * insulin resistance
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 8.889, rok: 2010

    Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPKα2 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions
    Trvalý link: http://hdl.handle.net/11104/0189808