Počet záznamů: 1

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

  1. 1.
    0349610 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Campa, D. - Pardini, Barbara - Naccarati, Alessio - Vodičková, Ludmila - Novotný, J. - Steinke, V. - Rahner, N. - Holinski-Feder, E. - Morak, M. - Schackert, H. K. - Görgens, H. - Kötting, J. - Betz, B. - Kloor, M. - Engel, C. - Büttner, R. - Propping, P. - Försti, A. - Hemminki, K. - Barale, R. - Vodička, Pavel - Canzian, F.
    Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.
    BMC Gastroenterology. Roč. 10, - (2010), s. 112-117 ISSN 1471-230X
    Grant CEP: GA ČR GA310/05/2626
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: colorectal cancer * insulin * GHSR
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.468, rok: 2010

    Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Pairwise tagging was used to select the 11 polymorphisms and the selected polymorphisms were genotyped in cases and controls from the Czech Republic and further verified on the German population. T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).
    Trvalý link: http://hdl.handle.net/11104/0006106