Počet záznamů: 1

Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease

  1. 1.
    0349468 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Noristani, H. N. - Olabarria, M. - Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio
    Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease.
    European Journal of Neuroscience. Roč. 32, č. 1 (2010), s. 71-79 ISSN 0953-816X
    Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: Alzheimer's disease * hippocampus * plasticity
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.658, rok: 2010

    In this work, we studied the hippocampal 5-HT innervation during the progression of Alzheimer’s disease in a triple transgenic mouse model of Alzheimer’s disease; which mimics the spatio-temporal and cognitive evolution of the disease. We observed a biphasic increase in serotonin transporter fibres in transgenic animals at 3 months and at 18 months of age; suggesting that this modifications imply a 5-HT sprouting, which may account for imbalanced serotonergic neurotransmission associated with Alzheimer’s disease cognitive impairment.
    Trvalý link: http://hdl.handle.net/11104/0189701