Počet záznamů: 1

Ca(2+) homeostasis, Ca(2+) signalling and somatodendritic vasopressin release in adult rat supraoptic nucleus neurones

  1. 1.
    0349377 - UEM-P 2011 RIV DE eng J - Článek v odborném periodiku
    Komori, Y. - Tanaka, M. - Kuba, M. - Ishii, M. - Abe, M. - Kitamura, N. - Verkhratsky, Alexei - Shibuya, I. - Dayanithi, Govindan
    Ca(2+) homeostasis, Ca(2+) signalling and somatodendritic vasopressin release in adult rat supraoptic nucleus neurones.
    Cell Calcium. Roč. 48, č. 6 (2010), s. 324-332 ISSN 0143-4160
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: hypothalamus * cell bodies * nerve terminals
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.553, rok: 2010

    Multiple mechanisms that maintain Ca2+ homeostasis and provide for Ca2+ signalling operate in the somatas and neurohypophysial nerve terminals of supraoptic nucleus (SON) neurones. We demonstrate that in the fully mature adult rats: (i) all four Ca2+ homeostatic pathways, the Na+/Ca2+ exchanger, the endoplasmic reticulum Ca2+ pump, the plasmalemmal Ca2+ pump and mitochondria, act complementary in clearing Ca2+ loads in SON neurones; (ii) somatodendritic AVP release closely correlates with intracellular [Ca2+]i dynamics; and (iii) Ca2+ homeostatic systems in the somatas of SON neurones differ from those expressed in their terminals.
    Trvalý link: http://hdl.handle.net/11104/0189633