Počet záznamů: 1

Differential Modulation of N-Type Calcium Channels by mu-Opioid Receptors in Oxytocinergic Versus Vasopressinergic Neurohypophysial Terminals

  1. 1.
    0349372 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Ortiz-Miranda, S. I. - Dayanithi, Govindan - Velazquez-Marrero, C. - Custer, E. E. - Treistman, S. N. - Lemos, J. R.
    Differential Modulation of N-Type Calcium Channels by mu-Opioid Receptors in Oxytocinergic Versus Vasopressinergic Neurohypophysial Terminals.
    Journal of Cellular Physiology. Roč. 225, č. 1 (2010), s. 276-288 ISSN 0021-9541
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: magnocellular neurons * G-protein modulation * neurohypophysis
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.986, rok: 2010

    Opioids modulate the electrical activity of magnocellular neurons (MCN) and inhibit neuropeptide release at their terminals in the neurohypophysis. We show that micro-opioid receptor (MOR) activation induces a stronger inhibition of oxytocin (OT) than vasopressin (AVP) release from isolated MCN terminals and found that N-type calcium channels in AVP terminals are differentially modulated by MOR.
    Trvalý link: http://hdl.handle.net/11104/0189629