Počet záznamů: 1

alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate

  1. 1.
    0349345 - BTO-N 2011 RIV GB eng J - Článek v odborném periodiku
    Tomasetti, M. - Strafella, E. - Staffolani, S. - Santarelli, L. - Neužil, Jiří - Guerrieri, R.
    alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate.
    British Journal of Cancer. Roč. 102, č. 8 (2010), s. 1224-1234 ISSN 0007-0920
    Výzkumný záměr: CEZ:AV0Z50520701
    Klíčová slova: Vitamins * prostate cancer * cell-death
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 4.831, rok: 2010

    A strategy to reduce the secondary effects of anti-cancer agents is to potentiate the therapeutic effect by their combination. A combination of vitamin K3 (VK3) and ascorbic acid (AA) exhibited an anti-cancer synergistic effect. The redox-silent vitamin E analogue alpha-tocopheryl succinate (alpha-TOS) was used in combination with VK3 and AA to evaluate their effect on prostate cancer cells. These cells were sensitive to alpha-TOS and VK3 treatment, but resistant to AA upto 3.2 mM. When combined, a synergistic effect was found for VK3-AA, whereas alpha-TOS-VK3 and alpha-TOS-AA combination showed an antagonist and additive effect, respectively. However, sub-lethal doses of AA-VK3 combination combined with a sub-toxic dose of alpha-TOS showed to induce cell death resembling autoschizis. Associated with this cell demise, lipid peroxidation, DNA damage, cytoskeleton alteration, lysosomal-mitochondrial perturbation, and release of cytochrome c without caspase activation were observed
    Trvalý link: http://hdl.handle.net/11104/0189611