Počet záznamů: 1

Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation

  1. 1.
    0349342 - BTO-N 2011 RIV US eng J - Článek v odborném periodiku
    Koudelka, S. - Mašek, J. - Neužil, Jiří - Turánek, J.
    Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation.
    Journal of Pharmaceutical Sciences. Roč. 99, č. 5 (2010), s. 2434-2443 ISSN 0022-3549
    Grant CEP: GA AV ČR(CZ) KAN200520703
    Výzkumný záměr: CEZ:AV0Z50520701
    Klíčová slova: Vitamin E analogues * liposome * cancer
    Kód oboru RIV: FR - Farmakologie a lékárnická chemie
    Impakt faktor: 3.031, rok: 2010

    alpha-Tocopheryl succinate (alpha-TOS) is a semisynthetic analogue of alpha-tocopherol with selective toxicity to the cancer cells and anticancer activity in vivo. Yet, no suitable formulation of alpha-TOS for medical application has been reported. Various formulations, for example, solutions in organic solvents, oil emulsions and vesicules prepared by spontaneous vesiculation, polyethylene glycol conjugates and liposomes of various compositions have been tested. We developed and characterised a stable lyophilised liposome-based alpha-TOS formulation. alpha-TOS (15 mol%) was incorporated into large oligolamellar vesicles (OLVs) composed of soy phosphatidylcholine (SPC) by the method of lipid film hydration followed by extrusion through polycarbonate filters. The data indicate good physical and chemical stability of the lyophilised preparation of alpha-TOS liposomes that can be used in clinical medicine
    Trvalý link: http://hdl.handle.net/11104/0189608