Počet záznamů: 1

Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats

  1. 1.
    0349311 - UOCHB-X 2011 RIV GB eng J - Článek v odborném periodiku
    Stofková, A. - Železná, Blanka - Romzová, Marianna - Uličná, O. - Kiss, A. - Skurlová, M. - Jurcovicová, J.
    Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats.
    Mediators of Inflammation. -, ID 398026 (2010), s. 1-12 ISSN 0962-9351
    Grant CEP: GA ČR GA305/06/0427; GA ČR GAP303/10/1368
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50520701
    Klíčová slova: adjuvant arthritis * feeding
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.059, rok: 2010

    We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1beta mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions.
    Trvalý link: http://hdl.handle.net/11104/0189583