Počet záznamů: 1

Synthesis of alpha-carboxyphosphinopeptides derived from norleucine

  1. 1.
    0349249 - UOCHB-X 2011 RIV AT eng J - Článek v odborném periodiku
    Pícha, Jan - Buděšínský, Miloš - Fiedler, Pavel - Šanda, Miloslav - Jiráček, Jiří
    Synthesis of alpha-carboxyphosphinopeptides derived from norleucine.
    Amino Acids. Roč. 39, č. 5 (2010), s. 1265-1280 ISSN 0939-4451
    Grant CEP: GA ČR GA203/06/1405; GA MŠk(CZ) LC06077
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: phosphinate * phosphinic * pseudopeptide * inhibitor
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 4.106, rok: 2010

    In the present study, we describe in detail the synthesis of a relatively rare class of phosphorus compounds, a-carboxyphosphinopeptides. We prepared several norleucine-derived a-carboxyphosphinic pseudopeptides of the general formula Nle-[PO(OH)]-Gly. These compounds could find important applications as inhibitors of metalloaminopeptidases.
    Trvalý link: http://hdl.handle.net/11104/0189540