Počet záznamů: 1

Der-p2 (Dermatophagoides pteronyssinus) allergen-like protein from the hard tick Ixodes ricinus - a novel member of ML (MD-2-related lipid-recognition) domain protein family

  1. 1.
    0349082 - BC-A 2011 RIV GB eng J - Článek v odborném periodiku
    Horáčková, Jana - Rudenko, Natalia - Golovchenko, Maryna - Grubhoffer, Libor
    Der-p2 (Dermatophagoides pteronyssinus) allergen-like protein from the hard tick Ixodes ricinus - a novel member of ML (MD-2-related lipid-recognition) domain protein family.
    Parasitology. Roč. 137, č. 7 (2010), s. 1139-1149 ISSN 0031-1820
    Grant CEP: GA ČR(CZ) GA524/06/1479
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: Der-p2 allergen-like protein * Ixodes ricinus * tick, * ML protein family * IgE-binding activity
    Kód oboru RIV: GJ - Choroby a škůdci zvířat, veterinární medicína
    Impakt faktor: 2.522, rok: 2010

    Analysis of the expression pattern showed that the gene encoding the tick Der-p2 allergen-like protein is strongly induced by the bloodmeal in gut and haemolymph throughout all tick developmental stages. Der-p2 allergenlike protein possesses a putative lipid-binding site, according to the comparisons with the related proteins. The ability of tick Der-p2 allergen-like protein to bind immunoglobulin E (IgE) was revealed. The presence of a putative lipid-binding domain in Der-p2 allergen-like protein and its ability to interact with IgE might indicate the involvement of the protein in the tick’s immune response.
    Trvalý link: http://hdl.handle.net/11104/0189416