Počet záznamů: 1

Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

  1. 1.
    0349066 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Viero, C. - Shibuya, I. - Kitamura, N. - Verkhratsky, Alexei - Fujihara, H. - Katoh, A. - Ueta, Y. - Zingg, H. H. - Chvátal, Alexandr - Syková, Eva - Dayanithi, Govindan
    Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy.
    CNS Neuroscience & Therapeutics. Roč. 16, č. 5 (2010), e138-e156 ISSN 1755-5930
    Grant CEP: GA ČR GA309/08/1381; GA ČR GA305/08/1384; GA ČR GA309/09/1597; GA MŠk(CZ) LC554
    Grant ostatní: GA MŠk(CZ) 1M0538
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: ACTH * analgesics * behavior
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.492, rok: 2010

    This review is focused on a small nine amino acid peptide, oxytocin, which is involved in a wide variety of physiological and pathological functions such as sexual activity, penile erection, ejaculation, pregnancy, uterus contraction, milk ejection, maternal behavior, osteoporosis, diabetes, cancer, social bonding, and stress, which makes oxytocin and its receptor potential candidates as targets for drug therapy. we address the issues of drug design and specificity and focus our discussion on recent findings on oxytocin and its heterotrimeric G protein-coupled receptor OTR.
    Trvalý link: http://hdl.handle.net/11104/0189402