Počet záznamů: 1

Distinct effects of Sonic hedgehog and Wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro

  1. 1.
    0349062 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Prajerová, Iva - Honsa, Pavel - Chvátal, Alexandr - Anděrová, Miroslava
    Distinct effects of Sonic hedgehog and Wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro.
    Neuroscience. Roč. 171, č. 3 (2010), s. 693-711 ISSN 0306-4522
    Grant CEP: GA ČR GA305/09/0717; GA MŠk(CZ) LC554
    Grant ostatní: GA ČR(CZ) GD309/08/H079; GA MŠk(CZ) 1M0538
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: morphogen * potassium currents * sodium currents
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.215, rok: 2010

    We explored the effect of two morphogens Sonic hedgehog and Wnt-7a on the proliferation, differentiation and membrane properties of neonatal neural stem/progenitor cells (NS/PCs) transduced with either Shh- or Wnt-7a. We found that Shh and Wnt-7a interfere differently with the process of neuronal differentiation and that they promote electrophysiologically and immunohistochemically distinct stages of neuronal differentiation in neonatal NS/PCs.
    Trvalý link: http://hdl.handle.net/11104/0189399